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Dietary n-3 fatty acid supplementation reduces superoxide production and chemiluminescence in a monocyte-enriched preparation of leukocytes.
- Source :
-
The American journal of clinical nutrition [Am J Clin Nutr] 1990 May; Vol. 51 (5), pp. 804-8. - Publication Year :
- 1990
-
Abstract
- Consuming substantial quantities of n-3 fatty acids reduces atherogenesis in experimental models of atherosclerosis. The mechanisms of this beneficial effect remain uncertain. Monocyte-derived tissue macrophages are associated with atherogenesis, and inhibition of monocyte inflammatory activity could, hypothetically, be helpful in preventing atherosclerosis. We observed that stimulated human monocyte and/or macrophage production of superoxide and the occurrence of monocyte chemiluminescence, two indices of monocyte inflammatory activity, were significantly reduced by the ingestion of 6 g n-3 fatty acids/d for 6 wk. This effect was associated with a reduction of stearic and arachidonic acids whereas eicosapentaenoic and docosahexaenoic acid concentrations rose significantly. These results indicate that modest dietary n-3 fatty acid supplementation can reduce stimulated human-monocyte free-radical production and may impair the capability of macrophages derived from monocytes to promote oxidation of low-density-lipoprotein cholesterol and associated cellular toxicity.
- Subjects :
- Adult
Arteriosclerosis prevention & control
Cod Liver Oil administration & dosage
Dietary Fats, Unsaturated pharmacology
Fatty Acids, Omega-3 pharmacology
Female
Free Radicals
Humans
Leukocytes analysis
Male
Middle Aged
Dietary Fats, Unsaturated administration & dosage
Fatty Acids, Omega-3 administration & dosage
Superoxides blood
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9165
- Volume :
- 51
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The American journal of clinical nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 2159210
- Full Text :
- https://doi.org/10.1093/ajcn/51.5.804