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Chiral Lewis base-assisted Brønsted acid (LBBA)-catalyzed enantioselective cyclization of 2-geranylphenols.
- Source :
-
Organic letters [Org Lett] 2011 Jun 17; Vol. 13 (12), pp. 3130-3. Date of Electronic Publication: 2011 May 19. - Publication Year :
- 2011
-
Abstract
- Chiral Lewis base-assisted Brønsted acids (Chiral LBBAs) have been designed as new organocatalysts for biomimetic enantioselective cyclization. A salt of a chiral phosphonous acid diester with FSO(3)H catalyzes the enantioselective cyclization of 2-geranylphenols to give the desired trans-fused cyclized products with high diastereo- and enantioselectivities (up to 98:2 dr and 93% ee).<br /> (© 2011 American Chemical Society)
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 13
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 21591803
- Full Text :
- https://doi.org/10.1021/ol201032t