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Ethyl 4-{1-[(2,4-dinitro-phen-yl)hydrazono]eth-yl}-5-(2-naphthyl-methoxy-meth-yl)isoxazole-3-carboxyl-ate.
- Source :
-
Acta crystallographica. Section E, Structure reports online [Acta Crystallogr Sect E Struct Rep Online] 2008 Dec 17; Vol. 65 (Pt 1), pp. o144-5. Date of Electronic Publication: 2008 Dec 17. - Publication Year :
- 2008
-
Abstract
- The title compound, C(26)H(23)N(5)O(8), was prepared and its structure investigated to further develop a working hypothesis for the essential binding pharmacophore for ligands of the System Xc- transporter [Patel et al. (2004 ▶). Neuropharmacology, 46, 273-284]. The hydrazone group displays an E geometry and the isoxazole double bond and C=N group of the hydrazone are in an s-cis relationship. The secondary amino NH group forms an intra-molecular N-H⋯O hydrogen bond to a ring nitro group. There is a dihedral angle of 44.27 (5)° between the isoxazole plane and the hydrazone group plane.
Details
- Language :
- English
- ISSN :
- 1600-5368
- Volume :
- 65
- Issue :
- Pt 1
- Database :
- MEDLINE
- Journal :
- Acta crystallographica. Section E, Structure reports online
- Publication Type :
- Academic Journal
- Accession number :
- 21581603
- Full Text :
- https://doi.org/10.1107/S1600536808041901