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Systematic computational prediction of protein interaction networks.

Authors :
Lees JG
Heriche JK
Morilla I
Ranea JA
Orengo CA
Source :
Physical biology [Phys Biol] 2011 Jun; Vol. 8 (3), pp. 035008. Date of Electronic Publication: 2011 May 13.
Publication Year :
2011

Abstract

Determining the network of physical protein associations is an important first step in developing mechanistic evidence for elucidating biological pathways. Despite rapid advances in the field of high throughput experiments to determine protein interactions, the majority of associations remain unknown. Here we describe computational methods for significantly expanding protein association networks. We describe methods for integrating multiple independent sources of evidence to obtain higher quality predictions and we compare the major publicly available resources available for experimentalists to use.

Details

Language :
English
ISSN :
1478-3975
Volume :
8
Issue :
3
Database :
MEDLINE
Journal :
Physical biology
Publication Type :
Academic Journal
Accession number :
21572181
Full Text :
https://doi.org/10.1088/1478-3975/8/3/035008