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Differential regional brain responses to induced maternal behavior in rats measured by cytochrome oxidase immunohistochemistry.
- Source :
-
Behavioural brain research [Behav Brain Res] 2011 Oct 01; Vol. 223 (2), pp. 293-6. Date of Electronic Publication: 2011 May 05. - Publication Year :
- 2011
-
Abstract
- Maternal behavior (MB) in rats is expressed under neural control of vomeronasal structures. Some of these regions exert an inhibitory role, such as the accessory olfactory bulb (AOB), while others exert an excitatory role, such as the medial preoptic area (MPOA). In previous studies, using 2-DG as a marker for neuron activity at neuron terminal level, we reported that AOB showed a decrease and MPOA an increase when compared with control rats (non-exposed to pups) during the display of MB. In the present study we used a different indicator of neuronal metabolic activity - cytochrome oxidase (COx) - to assess the activity of the same brain regions in relation to induced MB. The induced-MB females showed increased COx expression in the MPOA and reduced COx activity in the AOB in comparison with the control, non-MB group, consistent with our previous findings using 2-DG. Present results provide further evidence of a facilitatory role of MPOA and an inhibitory role of AOB in MB induction.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Autoradiography
Brain Chemistry drug effects
Electron Transport Complex IV antagonists & inhibitors
Female
Immunohistochemistry
Maternal Behavior drug effects
Olfactory Bulb enzymology
Olfactory Bulb physiology
Preoptic Area enzymology
Preoptic Area physiology
Rats
Rats, Wistar
Brain enzymology
Brain physiology
Electron Transport Complex IV metabolism
Maternal Behavior physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 223
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 21569801
- Full Text :
- https://doi.org/10.1016/j.bbr.2011.04.046