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Pediatric GFR estimating equations applied to adolescents in the general population.
- Source :
-
Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2011 Jun; Vol. 6 (6), pp. 1427-35. Date of Electronic Publication: 2011 May 12. - Publication Year :
- 2011
-
Abstract
- Background and Objectives: We examined the distribution of estimated GFR (eGFR) in a healthy cohort of adolescents to inform clinical and research use.<br />Design, Setting, Participants, & Measurements: Various creatinine-based (n = 3256) and/or cystatin C-based (n = 811) equations, including the recently developed complete and bedside equations from the Chronic Kidney Disease in Children (CKiD) study, were applied to U.S. adolescents 12 to 17 years of age participating in the 1999-2002 National Health and Nutrition Examination Survey (NHANES).<br />Results: The median serum creatinine and cystatin C were 0.7 mg/dl and 0.83 mg/L, respectively. The distribution of eGFR varied widely, with the median GFR ranging from a low of 96.6 ml/min per 1.73 m(2) (CKiD) to a high of 140.0 ml/min per 1.73 m(2) (original Schwartz). The proportions of participants with eGFRs <75 ml/min per 1.73 m(2) are as follows: bedside CKiD 8.9%, Counahan 6.3%, Leger 0.4%, original Schwartz 0%, Filler 1.3%, Grubb 3.1%, Bouvet 2.5%, CKiD 1.8%, and Zappitelli 5.6%. By any equation examined, no group of participants with eGFR ≤10th percentile had an increased prevalence of comorbid conditions consistent with a low measured GFR.<br />Conclusions: Most pediatric-specific GFR estimating equations resulted in 25% to 50% of the participants having an eGFR <100 ml/min per 1.73 m(2). However, participants with eGFR in the lower ranges did not have an increased prevalence of morbidities associated with chronic kidney disease. Clinical validation of creatinine- or cystatin C-based estimated GFRs in healthy children is needed before it is possible to screen the general population for chronic kidney disease.
- Subjects :
- Adolescent
Biomarkers blood
Child
Chronic Disease
Cohort Studies
Comorbidity
Creatinine blood
Cystatin C blood
Female
Health Surveys
Humans
Kidney Diseases blood
Kidney Diseases epidemiology
Kidney Diseases physiopathology
Male
Predictive Value of Tests
Prevalence
Reference Values
United States epidemiology
Glomerular Filtration Rate
Kidney physiopathology
Kidney Diseases diagnosis
Models, Biological
Subjects
Details
- Language :
- English
- ISSN :
- 1555-905X
- Volume :
- 6
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical journal of the American Society of Nephrology : CJASN
- Publication Type :
- Academic Journal
- Accession number :
- 21566103
- Full Text :
- https://doi.org/10.2215/CJN.06460710