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The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.
- Source :
-
Immunity [Immunity] 2011 May 27; Vol. 34 (5), pp. 715-28. Date of Electronic Publication: 2011 May 12. - Publication Year :
- 2011
-
Abstract
- Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo. Exposure of myeloid cells to hypoxia and/or bacterial products reduced KLF2 expression while inducing hypoxia inducible factor-1α (HIF-1α), findings that were recapitulated in human septic patients. Myeloid KLF2 was found to be a potent inhibitor of nuclear factor-kappaB (NF-κB)-dependent HIF-1α transcription and, consequently, a critical determinant of outcome in models of polymicrobial infection and endotoxemia. Collectively, these observations identify KLF2 as a tonic repressor of myeloid cell activation in vivo and an essential regulator of the innate immune system.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Bacterial Infections microbiology
Cell Line
Female
Hypoxia-Inducible Factor 1, alpha Subunit immunology
Immunity, Innate
Kruppel-Like Transcription Factors genetics
Lipopolysaccharides immunology
Male
Mice
Mice, Transgenic
Myeloid Cells immunology
NF-kappa B immunology
Bacterial Infections immunology
Kruppel-Like Transcription Factors immunology
Shock, Septic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4180
- Volume :
- 34
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 21565532
- Full Text :
- https://doi.org/10.1016/j.immuni.2011.04.014