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Simultaneous primary infection with HIV and CMV leading to severe pancytopenia, hepatitis, nephritis, perimyocarditis, myositis, and alopecia totalis.
- Source :
-
Klinische Wochenschrift [Klin Wochenschr] 1990 Feb 15; Vol. 68 (4), pp. 237-40. - Publication Year :
- 1990
-
Abstract
- Simultaneous primary infection with HIV and CMV in an 18-year-old woman led to an acute cytotoxic reaction, manifesting as pancytopenia, hepatitis, nephritis, perimyocarditis, and myositis. Within 14 days parameters indicating acute cell damage reverted to normal. Two weeks later transient alopecia totalis developed. Initially, HIV-antigen but no HIV antibodies were present. Within 3 weeks HIV-IgG antibodies appeared while HIV antigen disappeared. Anti-CMV-IgM was clearly and anti-CMV-IgG questionably positive; IgM persisted further, while IgG remained definitely undetectable. We speculate that a particular HIV-induced imbalance of the immune system led to a generalized severe cytotoxic reaction to a simultaneous infection with CMV.
- Subjects :
- Adolescent
Cytomegalovirus Infections diagnosis
Female
HIV Infections diagnosis
Humans
Opportunistic Infections diagnosis
Alopecia etiology
Cytomegalovirus Infections complications
HIV Infections complications
HIV-1 pathogenicity
Hepatitis, Viral, Human etiology
Myocarditis etiology
Myositis etiology
Nephritis etiology
Opportunistic Infections complications
Pancytopenia etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0023-2173
- Volume :
- 68
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Klinische Wochenschrift
- Publication Type :
- Academic Journal
- Accession number :
- 2156107
- Full Text :
- https://doi.org/10.1007/BF01662723