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Active metabolism of thyroid hormone during metamorphosis of amphioxus.
- Source :
-
Integrative and comparative biology [Integr Comp Biol] 2010 Jul; Vol. 50 (1), pp. 63-74. Date of Electronic Publication: 2010 May 24. - Publication Year :
- 2010
-
Abstract
- Thyroid hormones (THs), and more precisely the 3,3',5-triiodo-l-thyronine (T(3)) acetic derivative 3,3',5-triiodothyroacetic acid (TRIAC), have been shown to activate metamorphosis in amphioxus. However, it remains unknown whether TRIAC is endogenously synthesized in amphioxus and more generally whether an active TH metabolism is regulating metamorphosis. Here we show that amphioxus naturally produces TRIAC from its precursors T(3) and l-thyroxine (T(4)), supporting its possible role as the active TH in amphioxus larvae. In addition, we show that blocking TH production inhibits metamorphosis and that this effect is compensated by exogenous T(3), suggesting that a peak of TH production is important for advancement of proper metamorphosis. Moreover, several amphioxus genes encoding proteins previously proposed to be involved in the TH signaling pathway display expression profiles correlated with metamorphosis. In particular, thyroid hormone receptor (TR) and deiodinases gene expressions are either up- or down-regulated during metamorphosis and by TH treatments. Overall, these results suggest that an active TH metabolism controls metamorphosis in amphioxus, and that endogenous TH production and metabolism as well as TH-regulated metamorphosis are ancestral in the chordate lineage.<br /> (© The Author(s) 2010. Published by Oxford University Press.)
- Subjects :
- Animals
Antithyroid Agents pharmacology
Chordata, Nonvertebrate drug effects
Chordata, Nonvertebrate genetics
Chromatography, High Pressure Liquid
Gene Expression Regulation, Developmental
Larva drug effects
Larva genetics
Larva physiology
Metabolome
Propylthiouracil pharmacology
Thyroxine analogs & derivatives
Thyroxine pharmacology
Triiodothyronine metabolism
Chordata, Nonvertebrate physiology
Metamorphosis, Biological
Receptors, Thyroid Hormone metabolism
Triiodothyronine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7023
- Volume :
- 50
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Integrative and comparative biology
- Publication Type :
- Academic Journal
- Accession number :
- 21558188
- Full Text :
- https://doi.org/10.1093/icb/icq052