Back to Search
Start Over
Use of intraoperative ablation as an adjunct to surgical resection in the treatment of recurrent colorectal liver metastases.
- Source :
-
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract [J Gastrointest Surg] 2011 Jul; Vol. 15 (7), pp. 1168-72. Date of Electronic Publication: 2011 May 10. - Publication Year :
- 2011
-
Abstract
- Objective: To evaluate the role of intraoperative ablation as an adjunct to resection in patients with recurrent colorectal liver metastases (rCLM).<br />Methods: All patients undergoing curative-intent reoperative surgery for rCLM from 1992 to 2009 at a tertiary cancer center were included. Overall survival (OS) and recurrence-free survival (RFS) were compared between patients treated with resection alone or in combination with ablation.<br />Results: A total of 112 reoperative hepatectomies were performed, of which 16 were combined with ablation. The proportion of patients treated with resection and ablation increased from 0% to 41%. Patients undergoing resection and ablation had a greater tumor burden (median, 4 vs. 1, p < 0.0001) and higher baseline clinical risk scores (median, 3 vs. 2, p = 0.065) than patients undergoing resection alone. Patients undergoing resection and ablation had lower intraoperative blood loss than patients undergoing resection alone (344 vs. 877 ml, p = 0.018). Five-year OS from the time of surgery was 48.6%. In multivariable analysis, there was no significant difference in OS or RFS based on the treatment modality.<br />Conclusion: In patients with rCLM, the use of intraoperative ablation can extend the limits of surgical resection in patients with disease that might otherwise not be amenable to complete resection.
- Subjects :
- Colorectal Neoplasms mortality
Colorectal Neoplasms surgery
Disease-Free Survival
Female
Follow-Up Studies
Humans
Intraoperative Period
Liver Neoplasms mortality
Liver Neoplasms surgery
Male
Middle Aged
New York epidemiology
Retrospective Studies
Risk Factors
Survival Rate trends
Treatment Outcome
Catheter Ablation methods
Colorectal Neoplasms pathology
Hepatectomy methods
Liver Neoplasms secondary
Neoplasm Recurrence, Local surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4626
- Volume :
- 15
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
- Publication Type :
- Academic Journal
- Accession number :
- 21557021
- Full Text :
- https://doi.org/10.1007/s11605-011-1470-5