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Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis.
- Source :
-
Journal of clinical immunology [J Clin Immunol] 2011 Aug; Vol. 31 (4), pp. 606-14. Date of Electronic Publication: 2011 May 10. - Publication Year :
- 2011
-
Abstract
- Background: T-helper (Th) 22 and Th17 cells are implicated in the pathogenesis of autoimmune diseases. The roles of Th22 cells in the pathophysiology of rheumatoid arthritis (RA) remain unsettled.<br />Materials and Methods: CD4(+)IFNγ(-)IL17(-)IL-22(+) T cells (Th22 cells), CD4(+)IFNγ(-)IL-22(-)IL17(+) T cells (pure Th17 cells), CD4(+)IL17(+) T cells (Th17 cells), and CD4(+)IFNγ(+) T cells (Th1 cells) in RA, osteoarthritis patients, and healthy controls were examined by flow cytometry. Plasma IL-22 and IL-17 levels were examined by enzyme-linked immunosorbent assay.<br />Results: Th22 cells, pure Th17 cells, Th17 cells, and interleukin-22 were significantly elevated in RA patients compared with osteoarthritis and healthy controls, but there were no significant differences regarding Th1 cells and interleukin-17. Th22 cells showed a positive correlation with interleukin-22 as well as pure Th17 cells or Th17 cells in RA patients. Additionally, the percentages of Th22 cells, pure Th17 cells as well as Th17 cells correlated positively with both C-reactive protein levels and 28-joints disease activity score.<br />Conclusion: Together, our results indicated a possible role of Th22 pure Th17 cells and Th17 cells in RA, and blockade of the interleukin-22 may be a reasonable therapeutic strategy for RA.
- Subjects :
- Adult
Aged
Arthritis, Rheumatoid blood
Arthritis, Rheumatoid pathology
CD4 Antigens blood
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Humans
Interferon-gamma blood
Interleukin-17 blood
Lymphocyte Count
Male
Middle Aged
Osteoarthritis immunology
Th1 Cells immunology
Interleukin-22
Arthritis, Rheumatoid immunology
Interleukins blood
T-Lymphocytes, Helper-Inducer immunology
Th17 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2592
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21556937
- Full Text :
- https://doi.org/10.1007/s10875-011-9540-8