Back to Search Start Over

Function and regulation of ABCA1--membrane meso-domain organization and reorganization.

Authors :
Nagao K
Tomioka M
Ueda K
Source :
The FEBS journal [FEBS J] 2011 Sep; Vol. 278 (18), pp. 3190-203. Date of Electronic Publication: 2011 Jun 13.
Publication Year :
2011

Abstract

The ATP-binding cassette protein A1 (ABCA1) mediates the secretion of cellular-free cholesterol and phospholipids to an extracellular acceptor, apolipoprotein A-I, to form high-density lipoprotein. Because ABCA1 is a key factor in cholesterol homeostasis, elaborate transcriptional and post-transcriptional regulations of ABCA1 have evolved to maintain cholesterol homeostasis. Recent studies suggest that ABCA1 moves lipids not only between membranes but also within membranes to organize and reorganize membrane meso-domains to modulate cell proliferation and immunity.<br /> (© 2011 The Authors Journal compilation © 2011 FEBS.)

Details

Language :
English
ISSN :
1742-4658
Volume :
278
Issue :
18
Database :
MEDLINE
Journal :
The FEBS journal
Publication Type :
Academic Journal
Accession number :
21554545
Full Text :
https://doi.org/10.1111/j.1742-4658.2011.08170.x