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Function and regulation of ABCA1--membrane meso-domain organization and reorganization.
- Source :
-
The FEBS journal [FEBS J] 2011 Sep; Vol. 278 (18), pp. 3190-203. Date of Electronic Publication: 2011 Jun 13. - Publication Year :
- 2011
-
Abstract
- The ATP-binding cassette protein A1 (ABCA1) mediates the secretion of cellular-free cholesterol and phospholipids to an extracellular acceptor, apolipoprotein A-I, to form high-density lipoprotein. Because ABCA1 is a key factor in cholesterol homeostasis, elaborate transcriptional and post-transcriptional regulations of ABCA1 have evolved to maintain cholesterol homeostasis. Recent studies suggest that ABCA1 moves lipids not only between membranes but also within membranes to organize and reorganize membrane meso-domains to modulate cell proliferation and immunity.<br /> (© 2011 The Authors Journal compilation © 2011 FEBS.)
- Subjects :
- ATP Binding Cassette Transporter 1
ATP-Binding Cassette Transporters chemistry
ATP-Binding Cassette Transporters genetics
Animals
Apolipoproteins metabolism
Cholesterol metabolism
Gene Expression Regulation
Homeostasis
Humans
Mutation
Protein Processing, Post-Translational
Protein Transport
Tangier Disease genetics
Tangier Disease metabolism
ATP-Binding Cassette Transporters physiology
Membrane Microdomains metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1742-4658
- Volume :
- 278
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- The FEBS journal
- Publication Type :
- Academic Journal
- Accession number :
- 21554545
- Full Text :
- https://doi.org/10.1111/j.1742-4658.2011.08170.x