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Enhanced solubility and bioavailability of flurbiprofen by cycloamylose.
- Source :
-
Archives of pharmacal research [Arch Pharm Res] 2011 Mar; Vol. 34 (3), pp. 391-7. Date of Electronic Publication: 2011 May 06. - Publication Year :
- 2011
-
Abstract
- The effect of cycloamylose on the aqueous solubility of flurbiprofen was investigated. To improve the solubility and bioavailability of flurbiprofen (poor water solubility), a solid dispersion was spray dried with a solution of flurbiprofen and cycloamylose at a weight ratio of 1:1. The physicochemical properties of solid dispersions were investigated using SEM, DSC, and X-ray diffraction. The dissolution and bioavailability in rats were evaluated compared with a commercial product. Cycloamylose increased solubility of flurbiprofen approximately 12-fold and dissolution of it by 2-fold. Flurbiprofen was present in an unchanged crystalline state, and cycloamylose was a solubilizing agent for flurbiprofen in this solid dispersion. Furthermore, the dispersion gave higher AUC and C(max) values compared with the commercial product, indicating that it improved the oral bioavailability of flurbiprofen in rats. Thus, the solid dispersion may be useful to deliver flurbiprofen with enhanced bioavailability without changes in crystalline structure.
- Subjects :
- Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal blood
Area Under Curve
Biological Availability
Calorimetry, Differential Scanning
Drug Compounding
Flurbiprofen blood
Male
Microscopy, Electron, Scanning
Rats
Rats, Sprague-Dawley
Solubility
Surface Properties
X-Ray Diffraction
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics
Cyclodextrins chemistry
Excipients chemistry
Flurbiprofen chemistry
Flurbiprofen pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1976-3786
- Volume :
- 34
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of pharmacal research
- Publication Type :
- Academic Journal
- Accession number :
- 21547670
- Full Text :
- https://doi.org/10.1007/s12272-011-0306-x