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Cardiovascular regulation profile predicts developmental trajectory of BMI and pediatric obesity.
- Source :
-
Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2011 Sep; Vol. 19 (9), pp. 1818-25. Date of Electronic Publication: 2011 May 05. - Publication Year :
- 2011
-
Abstract
- The present study examined the role of cardiovascular regulation in predicting pediatric obesity. Participants for this study included 268 children (141 girls) obtained from a larger ongoing longitudinal study. To assess cardiac vagal regulation, resting measures of respiratory sinus arrhythmia (RSA) and RSA change (vagal withdrawal) to three cognitively challenging tasks were derived when children were 5.5 years of age. Heart period (HP) and HP change (heart rate (HR) acceleration) were also examined. Height and weight measures were collected when children were 5.5, 7.5, and 10.5 years of age. Results indicated that physiological regulation at age 5.5 was predictive of both normal variations in BMI development and pediatric obesity at age 10.5. Specifically, children with a cardiovascular regulation profile characterized by lower levels of RSA suppression and HP change experienced significantly greater levels of BMI growth and were more likely to be classified as overweight/at-risk for overweight at age 10.5 compared to children with a cardiovascular regulation profile characterized by high levels of RSA suppression and HP change. However, a significant interaction with racial status was found suggesting that the association between cardiovascular regulation profile and BMI growth and pediatric obesity was only significant for African-American children. An autonomic cardiovascular regulation profile consisting of low parasympathetic activity represents a significant individual risk factor for the development of pediatric obesity, but only for African-American children. Mechanisms by which early physiological regulation difficulties may contribute to the development of pediatric obesity are discussed.
- Subjects :
- Black or African American
Arrhythmia, Sinus epidemiology
Arrhythmia, Sinus ethnology
Arrhythmia, Sinus etiology
Autonomic Nervous System growth & development
Autonomic Nervous System physiopathology
Body Mass Index
Cardiovascular System innervation
Cardiovascular System physiopathology
Child, Preschool
Female
Heart Rate
Humans
Longitudinal Studies
Male
North Carolina epidemiology
Obesity ethnology
Obesity physiopathology
Overweight epidemiology
Overweight ethnology
Overweight physiopathology
Parasympathetic Nervous System growth & development
Parasympathetic Nervous System physiopathology
Risk Factors
Cardiovascular System growth & development
Child Development
Homeostasis
Models, Biological
Obesity epidemiology
Stress, Physiological
Weight Gain ethnology
Subjects
Details
- Language :
- English
- ISSN :
- 1930-739X
- Volume :
- 19
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Obesity (Silver Spring, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 21546929
- Full Text :
- https://doi.org/10.1038/oby.2011.98