Back to Search
Start Over
Multiple sclerosis: relations between MRI and CT findings, cerebrospinal fluid parameters and clinical features.
- Source :
-
Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 1990; Vol. 92 (1), pp. 49-56. - Publication Year :
- 1990
-
Abstract
- Cerebral MRI and CT findings were compared with various cerebrospinal fluid (CSF) parameters and clinical features in 75 patients with multiple sclerosis (MS). There were positive correlations between CSF albumin as a parameter of blood-brain barrier function and morphological parameters, namely the number of nonperiventricular foci and periventricular involvement demonstrated by MRI and ventricular enlargement as shown by CT. Apart from positive correlations between the number of nonperiventricular foci and CSF levels of IgA and IgG, including the IgG synthetic rate, no other correlations were found between CSF parameters (leucocyte count and immunoglobulin concentrations) and morphological findings. The unremitting-progressive type of MS was distinguished from the relapsing-remitting form by a lower CSF leucocyte count and a higher degree of disability, but there was no difference between the morphological findings in the two forms. Positive correlations were found between degree of disability and both periventricular involvement in the MRI and CT evidence of ventricular enlargement. In terms of correlations with the duration of disease, cerebral MRI proved to be far superior to CSF evaluations.
- Subjects :
- Adolescent
Adult
Aged
Albumins cerebrospinal fluid
Blood-Brain Barrier
Female
Humans
Immunoglobulin A cerebrospinal fluid
Immunoglobulin G biosynthesis
Immunoglobulin G cerebrospinal fluid
Leukocyte Count
Leukocytes analysis
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis cerebrospinal fluid
Multiple Sclerosis diagnosis
Multiple Sclerosis pathology
Time Factors
Tomography, X-Ray
Multiple Sclerosis physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0303-8467
- Volume :
- 92
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical neurology and neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 2154355
- Full Text :
- https://doi.org/10.1016/0303-8467(90)90007-r