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Genomic investigation of year-long and multigenerational exposures of fathead minnow to the munitions compound RDX.
- Source :
-
Environmental toxicology and chemistry [Environ Toxicol Chem] 2011 Aug; Vol. 30 (8), pp. 1852-64. Date of Electronic Publication: 2011 Jun 14. - Publication Year :
- 2011
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Abstract
- We assessed the impacts of exposure to an environmentally representative concentration (0.83 mg/L) of the explosive cyclotrimethylenetrinitramine (RDX) on fathead minnows (Pimephales promelas) in one-year and multigenerational bioassays. In the one-year bioassay, impacts were assessed by statistical comparisons of females from breeding groups reared in control or RDX-exposure conditions. The RDX had no significant effect on gonadosomatic index or condition factor assayed at 1 d and at one, three, six, nine, and 12 months. The liver-somatic index was significantly increased versus controls only at the 12-month timepoint. RDX had no significant effect on live-prey capture rates, egg production, or fertilization. RDX caused minimal differential-transcript expression with no consistent discernable effect on gene-functional categories for either brain or liver tissues in the one-year exposure. In the multigenerational assay, the effects of acute (96 h) exposure to RDX were compared in fish reared to the F(2) generation in either control or RDX-exposure conditions. Enrichment of gene functions including neuroexcitatory glutamate metabolism, sensory signaling, and neurological development were observed comparing control-reared and RDX-reared fish. Our results indicated that exposure to RDX at a concentration representing the highest levels observed in the environment (0.83 mg/L) had limited impacts on genomic, individual, and population-level endpoints in fathead minnows in a one-year exposure. However, multigenerational exposures altered transcript expression related to neural development and function. Environ.<br /> (Copyright © 2011 SETAC.)
- Subjects :
- Animals
Biological Assay
Brain drug effects
Brain metabolism
Cyprinidae growth & development
Cyprinidae metabolism
Dose-Response Relationship, Drug
Environmental Exposure analysis
Explosive Agents metabolism
Female
Fertilization
Fish Proteins genetics
Fish Proteins metabolism
Gene Expression drug effects
Genome drug effects
Liver drug effects
Liver metabolism
Male
Triazines metabolism
Water Pollutants, Chemical metabolism
Cyprinidae genetics
Explosive Agents toxicity
Triazines toxicity
Water Pollutants, Chemical toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1552-8618
- Volume :
- 30
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Environmental toxicology and chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21538488
- Full Text :
- https://doi.org/10.1002/etc.558