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Clinical features of lung cancer in smokers with light and mild chronic obstructive pulmonary disease: a retrospective analysis of Japanese surgical cases.
- Source :
-
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery [Eur J Cardiothorac Surg] 2011 Dec; Vol. 40 (6), pp. 1439-43. Date of Electronic Publication: 2011 May 06. - Publication Year :
- 2011
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Abstract
- Objectives: We estimated the influence of chronic obstructive pulmonary disease (COPD) upon the clinicopathological characteristics of lung cancer (LC) in Japanese surgical cases by comparing LC cases in non-COPD smokers.<br />Method: A consecutive cohort comprising 157 COPD patients (78 in Global Initiative for Obstructive Lung Disease-1 (GOLD-1) and 79 in GOLD-2) and 374 non-COPD smoker-LC patients were enrolled in this study. Comparative analyses of the clinicopathological features of these two groups, including clinical outcomes, were performed.<br />Results: By analyzing all cases, we found that LC patients with COPD were older on average, more likely to be male, and heavier smokers than LC patients without COPD. In sub-analysis involving matched patient backgrounds, histological differentiation grade of LC in smokers with COPD was lower than in LC smokers without COPD, although distribution of clinical stages and histological types of LCs did not differ between smokers with and without COPD. The 5-year-survival rate in COPD patients was poorer than in non-COPD smokers in terms of both overall (38% vs 54%) and cancer-related mortality (45% vs 63%). By single-variant risk analysis, COPD became a prognostic factor.<br />Conclusion: We concluded from our analysis that COPD-related LC may have a higher malignant potential than LC in non-COPD smokers, as the histological differentiation grade and clinical outcomes were poorer.<br /> (Copyright © 2011 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Age Factors
Aged
Aged, 80 and over
Epidemiologic Methods
Female
Forced Expiratory Volume physiology
Humans
Lung Neoplasms pathology
Lung Neoplasms physiopathology
Lung Neoplasms surgery
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Pneumonectomy methods
Prognosis
Pulmonary Disease, Chronic Obstructive physiopathology
Sex Factors
Smoking adverse effects
Treatment Outcome
Lung Neoplasms complications
Pulmonary Disease, Chronic Obstructive complications
Subjects
Details
- Language :
- English
- ISSN :
- 1873-734X
- Volume :
- 40
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 21530296
- Full Text :
- https://doi.org/10.1016/j.ejcts.2011.03.017