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Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2011 Jul; Vol. 205 (1), pp. 79.e1-5. Date of Electronic Publication: 2011 Feb 27. - Publication Year :
- 2011
-
Abstract
- Objective: We sought to evaluate the interaction between repeated-course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2 years.<br />Study Design: We conducted nested case-control analysis of a randomized controlled trial of single- vs repeated-course antenatal corticosteroids. Cases had mental and/or psychomotor delay at age 2 years. Controls had normal neurodevelopment. Previous analyses of 125 cases and 147 controls identified 4 inflammation gene polymorphisms associated with neurodevelopmental delay at age 2 years.<br />Results: The interaction between repeated-course corticosteroids and the interleukin (IL)-6 -174 genotype with neurodevelopmental delay was significant (P = .046). The IL-6 -174 GG genotype was associated with neurodevelopmental delay at age 2 years in the single-course corticosteroid group (odds ratio, 6.47; 95% confidence interval, 1.86-22.50). Exposure to repeated-course antenatal corticosteroids abrogated this genotype effect (odds ratio, 1.30; 95% confidence interval, 0.48-3.54). Results were unchanged after controlling for potential confounders.<br />Conclusion: Repeated-course antenatal steroids may reduce the increased risk of neurodevelopmental delay at age 2 years associated with IL-6 -174 GG genotype.<br /> (Copyright © 2011 Mosby, Inc. All rights reserved.)
- Subjects :
- Adrenal Cortex Hormones therapeutic use
Case-Control Studies
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Inflammation genetics
Male
Randomized Controlled Trials as Topic
Adrenal Cortex Hormones adverse effects
Central Nervous System drug effects
Central Nervous System growth & development
Child Development drug effects
Interleukin-6 genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 205
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 21529753
- Full Text :
- https://doi.org/10.1016/j.ajog.2011.02.061