The relationship between serum phosphate levels with childhood obesity and insulin resistance.

Aim: To investigate the relationship between serum phosphate levels with obesity and insulin resistance in childhood.
Methods: A total of 298 children and adolescents (190 obese subjects and 108 controls) were included in the study. Serum glucose, insulin, phosphate, calcium and alkaline phosphatase levels were measured after 12 h fasting at 08:00-08:30 h. We assessed insulin sensitivity by using the HOMA-IR (homeostasis model of insulin resistance) index as a surrogate marker of insulin resistance.
Results: Serum levels of phosphate were significantly lower in the 6- to 12-year-old obese subjects than controls (p = 0.02, p < 0.05). At the same time, there was a moderate negative correlation between serum phosphate levels and the HOMA-IR index in the 6- to 12-year-old IR (-) obese children (r = -0.26, p = 0.02).
Conclusions: Low serum phosphate levels could contribute to the development of insulin resistance in 6- to 12-year-old obese children.