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[Brain metastasis of breast tumors and blood brain barrier].
- Source :
-
Bulletin du cancer [Bull Cancer] 2011 Apr; Vol. 98 (4), pp. 385-9. - Publication Year :
- 2011
-
Abstract
- Brain metastases are prevalent in solid tumours and lymphomas. They are associated with poor survival. The brain is regarded as a sanctuary site for metastatic tumour cells where they exist partially protected from drugs by the blood brain barrier. Amongst the different molecular sub-types of breast cancer, HER2 positive tumours and triple negative tumours exhibit the highest incidence of brain metastasis. Specific strategies are needed to fight brain metastatic disease. Preclinical models for brain metastasis have been developed, yielding mechanistic molecular knowledge and new therapeutic approaches.
- Subjects :
- Antineoplastic Agents pharmacokinetics
Brain Neoplasms blood supply
Brain Neoplasms chemistry
Brain Neoplasms drug therapy
Brain Neoplasms metabolism
Breast Neoplasms metabolism
Female
Humans
Neoplasm Metastasis pathology
Neovascularization, Pathologic etiology
Receptor, ErbB-2 metabolism
Blood-Brain Barrier
Brain Neoplasms secondary
Breast Neoplasms pathology
Subjects
Details
- Language :
- French
- ISSN :
- 1769-6917
- Volume :
- 98
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bulletin du cancer
- Publication Type :
- Academic Journal
- Accession number :
- 21527366
- Full Text :
- https://doi.org/10.1684/bdc.2011.1336