Back to Search
Start Over
Synthesis of novel N-hydroxy heterocycles via intramolecular reductive cyclization of diketoximes by NaBH3CN.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2011 Jun 21; Vol. 9 (12), pp. 4642-52. Date of Electronic Publication: 2011 Apr 28. - Publication Year :
- 2011
-
Abstract
- A simple and efficient protocol for the construction of substituted piperazines, piperidines, thiomorpholines, decahydroquinolines, perhydrocyclopenta[b]pyridine, and pyrrolidines bearing N-hydroxy substituents through intramolecular reductive cyclization of diketoximes using sodium cyanoborohydride is described.
- Subjects :
- Borohydrides chemistry
Cyclization
Molecular Structure
Oximes chemistry
Stereoisomerism
Chemistry, Pharmaceutical
Morpholines chemical synthesis
Piperazines chemical synthesis
Piperidines chemical synthesis
Pyridines chemical synthesis
Pyrrolidines chemical synthesis
Quinolines chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 9
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21526255
- Full Text :
- https://doi.org/10.1039/c1ob05232b