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Neuronal autophagy as a mediator of life and death: contrasting roles in chronic neurodegenerative and acute neural disorders.
- Source :
-
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [Neuroscientist] 2012 Jun; Vol. 18 (3), pp. 224-36. Date of Electronic Publication: 2011 Apr 27. - Publication Year :
- 2012
-
Abstract
- Autophagy is a cellular mechanism for degrading proteins and organelles. It was first described as a physiological process essential for cellular health and survival, and this is its role in most cells. However, it can also be a mediator of cell death, either by the triggering of apoptosis or by an independent "autophagic" cell death mechanism. This duality is important in the central nervous system, where the activation of autophagy has recently been shown to be protective in certain chronic neurodegenerative diseases but deleterious in acute neural disorders such as stroke and hypoxic/ischemic injury. The authors here discuss these distinct roles of autophagy in the nervous system with a focus on the role of autophagy in mediating neuronal death. The development of new therapeutic strategies based on the manipulation of autophagy will need to take into account these opposing roles of autophagy.
- Subjects :
- Animals
Humans
Hypoxia-Ischemia, Brain physiopathology
Nerve Degeneration physiopathology
Neurodegenerative Diseases physiopathology
Stroke physiopathology
Autophagy physiology
Hypoxia-Ischemia, Brain pathology
Nerve Degeneration pathology
Neurodegenerative Diseases pathology
Stroke pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1089-4098
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 21525331
- Full Text :
- https://doi.org/10.1177/1073858411404948