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[West Nile virus. II. Immunopathophysiology in humans].
- Source :
-
Medecine sciences : M/S [Med Sci (Paris)] 2011 Apr; Vol. 27 (4), pp. 382-6. Date of Electronic Publication: 2011 Apr 28. - Publication Year :
- 2011
-
Abstract
- Since its emergence in 1999 in America, West Nile virus (WNV) has become the leading cause of arboviral encephalitis in the United States. The infection is often asymptomatic but, when clinical manifestations occur, a broad range of symptoms is observed from flu-like symptoms to more serious neurological disorders that can sometimes lead to death. No treatment or vaccine is available for humans. Ongoing studies are trying to understand the host-virus dynamics that lead to the development of severe neurological symptoms in a minority of infected subjects. The amount of knowledge that was gained from parallel studies in animals and humans, comparing asymptomatic and symptomatic individuals, and using what was known of other Flaviviruses, will eventually translate to the development of potential therapeutic and prophylactic solutions. This review presents a synthesis of the most relevant findings concerning the immune response to WNV and its impact on disease outcome and gives an overview of the most promising therapeutic and prophylactic solutions.
- Subjects :
- Animals
Antibodies, Viral biosynthesis
Antibodies, Viral immunology
Antiviral Agents therapeutic use
Asymptomatic Diseases
Biomarkers
Brain virology
Disease Outbreaks
Female
Humans
Immunity, Cellular
Inflammation
Lymphoid Tissue virology
Male
Microglia virology
Neurons virology
Risk Factors
Virus Internalization
Virus Replication
West Nile Fever drug therapy
West Nile Fever epidemiology
West Nile Fever immunology
West Nile Fever prevention & control
West Nile Fever virology
West Nile Fever physiopathology
West Nile virus physiology
Subjects
Details
- Language :
- French
- ISSN :
- 0767-0974
- Volume :
- 27
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Medecine sciences : M/S
- Publication Type :
- Academic Journal
- Accession number :
- 21524402
- Full Text :
- https://doi.org/10.1051/medsci/2011274013