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[The activity of 2',5'-oligoadenylate-synthetase in rat spleen lymphocytes in the chronic ethanol intoxication and administration of zinc acetate].
- Source :
-
Ukrains'kyi biokhimichnyi zhurnal (1999 ) [Ukr Biokhim Zh (1999)] 2010 Jul-Aug; Vol. 82 (4), pp. 100-4. - Publication Year :
- 2010
-
Abstract
- It was shown that the activity of interferon-induced enzyme 2',5'-oligoadenylate-synthetase is suppressed in rat spleen lymphocytes under the chronic alcohol intoxication. The values of enzyme activity were minimal under the long-term action of etanol (21 day). The combined administration of zinc acetate and etanol to rats causes the increase of enzyme activity, the effect is most expressed on the late stages of alcohol intoxication development.
- Subjects :
- Alcoholism immunology
Alcoholism prevention & control
Animals
Dose-Response Relationship, Drug
Ethanol administration & dosage
Lymphocytes enzymology
Lymphocytes immunology
Male
Rats
Rats, Wistar
Spleen cytology
Spleen enzymology
Spleen immunology
Zinc Acetate administration & dosage
Zinc Acetate therapeutic use
2',5'-Oligoadenylate Synthetase metabolism
Alcoholism enzymology
Ethanol toxicity
Lymphocytes drug effects
Spleen drug effects
Zinc Acetate pharmacology
Subjects
Details
- Language :
- Ukrainian
- Volume :
- 82
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Ukrains'kyi biokhimichnyi zhurnal (1999 )
- Publication Type :
- Academic Journal
- Accession number :
- 21516723