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Relationship between diffuse pulmonary fibrosis, alveolar proteinosis, and granulocyte-macrophage colony stimulating factor autoantibodies.
- Source :
-
Respiratory care [Respir Care] 2011 Oct; Vol. 56 (10), pp. 1608-10. Date of Electronic Publication: 2011 Apr 19. - Publication Year :
- 2011
-
Abstract
- Extensive pulmonary fibrosis is a rare occurrence in pulmonary alveolar proteinosis. We report 2 cases that have interesting implications. A female patient was diagnosed with autoimmune pulmonary alveolar proteinosis that evolved over 7 years into diffuse fibrosis. In a male patient with diffuse fibrosis we incidentally detected electron microscopic features of alveolar surfactant accumulation and positive autoantibodies to granulocyte-macrophage colony stimulating factor. In the male patient we speculated that the pulmonary fibrosis might have been preceded by an asymptomatic phase of autoimmune pulmonary alveolar proteinosis, and that we should investigate the involvement of surfactant dysfunction in the pathogenesis of fibrotic lung disease.
- Subjects :
- Blood Gas Analysis
Fatal Outcome
Female
Humans
Male
Middle Aged
Pulmonary Alveolar Proteinosis diagnostic imaging
Pulmonary Alveolar Proteinosis immunology
Pulmonary Fibrosis diagnostic imaging
Respiratory Function Tests
Tomography, X-Ray Computed
Autoantibodies blood
Granulocyte-Macrophage Colony-Stimulating Factor immunology
Pulmonary Alveolar Proteinosis complications
Pulmonary Fibrosis complications
Pulmonary Surfactants metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0020-1324
- Volume :
- 56
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Respiratory care
- Publication Type :
- Academic Journal
- Accession number :
- 21513605
- Full Text :
- https://doi.org/10.4187/respcare.01054