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Two novel biphenyl dimers from the heartwood of Caesalpinia sappan.
- Source :
-
Fitoterapia [Fitoterapia] 2011 Jul; Vol. 82 (5), pp. 762-6. Date of Electronic Publication: 2011 Apr 13. - Publication Year :
- 2011
-
Abstract
- Two novel biphenyl dimers, caesappanin A (1) and B (2), were isolated from the ethanol extract of the heartwood of Caesalpinia sappan. Their structures were elucidated on the basis of spectroscopic data including IR, HRESIMS, 1D and 2D NMR. Preliminary bioassays showed that compound 1 possessed potent cytotoxic effects against 4 cell lines including HCT-8, BGC-823, A549 and A2780 with IC(50) between 1.67μM and 4.88μM.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic pharmacology
Antineoplastic Agents, Phytogenic therapeutic use
Biphenyl Compounds pharmacology
Biphenyl Compounds therapeutic use
Cell Line, Tumor
Humans
Molecular Structure
Phytotherapy
Plant Extracts pharmacology
Plant Extracts therapeutic use
Wood
Antineoplastic Agents, Phytogenic isolation & purification
Biphenyl Compounds isolation & purification
Caesalpinia chemistry
Plant Extracts chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 82
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 21511014
- Full Text :
- https://doi.org/10.1016/j.fitote.2011.03.010