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Epstein-Barr virus DNA quantification and follow-up in Tunisian nasopharyngeal carcinoma patients.

Authors :
Hassen E
Farhat K
Gabbouj S
Bouaouina N
Abdelaziz H
Chouchane L
Source :
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2011 May; Vol. 16 (3), pp. 274-80.
Publication Year :
2011

Abstract

The prognostic value of the Epstein-Barr virus (EBV) DNA load in sera of nasopharyngeal carcinoma (NPC) patients measured before any treatment, after treatment and before relapse was assessed. The real-time polymerase chain reaction was used to detect the viral load levels among 74 NPC subjects. Patients were followed up for a period going from 1 to 6 years (median 4 years). Before treatment, the EBV DNA load was correlated with lymph node involvement and advanced stages. After treatment, the viral load level declined significantly and patients presenting a viral load level lower than 1000 copies/ml showed a better overall survival (OS). Moreover, a significant result was found when the 6-year OS rates of patients having fewer or more than 15,000 copies/ml of viral load before relapse were compared. These results suggest that the EBV DNA load quantification after treatment may be a useful predictor of disease progression and survival.

Details

Language :
English
ISSN :
1366-5804
Volume :
16
Issue :
3
Database :
MEDLINE
Journal :
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Publication Type :
Academic Journal
Accession number :
21506698
Full Text :
https://doi.org/10.3109/1354750X.2010.551409