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Epstein-Barr virus DNA quantification and follow-up in Tunisian nasopharyngeal carcinoma patients.
- Source :
-
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2011 May; Vol. 16 (3), pp. 274-80. - Publication Year :
- 2011
-
Abstract
- The prognostic value of the Epstein-Barr virus (EBV) DNA load in sera of nasopharyngeal carcinoma (NPC) patients measured before any treatment, after treatment and before relapse was assessed. The real-time polymerase chain reaction was used to detect the viral load levels among 74 NPC subjects. Patients were followed up for a period going from 1 to 6 years (median 4 years). Before treatment, the EBV DNA load was correlated with lymph node involvement and advanced stages. After treatment, the viral load level declined significantly and patients presenting a viral load level lower than 1000 copies/ml showed a better overall survival (OS). Moreover, a significant result was found when the 6-year OS rates of patients having fewer or more than 15,000 copies/ml of viral load before relapse were compared. These results suggest that the EBV DNA load quantification after treatment may be a useful predictor of disease progression and survival.
- Subjects :
- Adolescent
Adult
Aged
Case-Control Studies
Child
Disease-Free Survival
Epstein-Barr Virus Infections blood
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Nasopharyngeal Neoplasms diagnosis
Nasopharyngeal Neoplasms mortality
Neoplasm Recurrence, Local mortality
Prognosis
Tunisia
Viral Load
Young Adult
Biomarkers, Tumor blood
DNA, Viral blood
Epstein-Barr Virus Infections virology
Herpesvirus 4, Human genetics
Nasopharyngeal Neoplasms virology
Neoplasm Recurrence, Local virology
Subjects
Details
- Language :
- English
- ISSN :
- 1366-5804
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
- Publication Type :
- Academic Journal
- Accession number :
- 21506698
- Full Text :
- https://doi.org/10.3109/1354750X.2010.551409