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Atrial natriuretic peptide in the renal response to an acute protein load.
- Source :
-
International journal of clinical pharmacology research [Int J Clin Pharmacol Res] 1990; Vol. 10 (4), pp. 211-6. - Publication Year :
- 1990
-
Abstract
- A high protein meal acutely stimulates the glomerular filtration rate. In order to assess the possible role of atrial natriuretic peptide (ANP) as a mediator of this renal response, the ANP plasma concentrations were measured with a sensitive radioimmunoassay method before and after a large protein load (1.5 g/kg body weight given as a meat meal). Creatinine clearance increased significantly while fractional excretion of sodium remained constant. ANP plasma concentrations did not change after the protein load and the intra-individual variations of creatinine clearance were not correlated with the intra-individual changes in ANP plasma concentrations. It was concluded that ANP was probably not involved in the renal haemodynamic changes observed after a large protein load.
Details
- Language :
- English
- ISSN :
- 0251-1649
- Volume :
- 10
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of clinical pharmacology research
- Publication Type :
- Academic Journal
- Accession number :
- 2150404