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Synthesis and characterization of silver/montmorillonite/chitosan bionanocomposites by chemical reduction method and their antibacterial activity.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2011; Vol. 6, pp. 271-84. Date of Electronic Publication: 2011 Jan 27. - Publication Year :
- 2011
-
Abstract
- Silver nanoparticles (AgNPs) of a small size were successfully synthesized using the wet chemical reduction method into the lamellar space layer of montmorillonite/chitosan (MMT/Cts) as an organomodified mineral solid support in the absence of any heat treatment. AgNO3, MMT, Cts, and NaBH4 were used as the silver precursor, the solid support, the natural polymeric stabilizer, and the chemical reduction agent, respectively. MMT was suspended in aqueous AgNO3/Cts solution. The interlamellar space limits were changed (d-spacing = 1.24-1.54 nm); therefore, AgNPs formed on the interlayer and external surface of MMT/Cts with d-average = 6.28-9.84 nm diameter. Characterizations were done using different methods, ie, ultraviolet-visible spectroscopy, powder X-ray diffraction, transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray fluorescence spectrometry, and Fourier transform infrared spectroscopy. Silver/montmorillonite/chitosan bionanocomposite (Ag/MMT/Cts BNC) systems were examined. The antibacterial activity of AgNPs in MMT/Cts was investigated against Gram-positive bacteria, ie, Staphylococcus aureus and methicillin-resistant S. aureus and Gram-negative bacteria, ie, Escherichia coli, E. coli O157:H7, and Pseudomonas aeruginosa by the disc diffusion method using Mueller Hinton agar at different sizes of AgNPs. All of the synthesized Ag/MMT/Cts BNCs were found to have high antibacterial activity. These results show that Ag/MMT/Cts BNCs can be useful in different biological research and biomedical applications, including surgical devices and drug delivery vehicles.
- Subjects :
- Anti-Bacterial Agents chemical synthesis
Chitosan chemical synthesis
Escherichia coli drug effects
Metal Nanoparticles ultrastructure
Microbial Sensitivity Tests
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Nanocomposites ultrastructure
Nanomedicine
Oxidation-Reduction
Powder Diffraction
Pseudomonas aeruginosa drug effects
Spectrophotometry
Spectrophotometry, Atomic
Spectroscopy, Fourier Transform Infrared
Staphylococcus aureus drug effects
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Bentonite chemistry
Bentonite pharmacology
Chitosan chemistry
Chitosan pharmacology
Metal Nanoparticles chemistry
Nanocomposites chemistry
Silver chemistry
Silver pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 21499424
- Full Text :
- https://doi.org/10.2147/IJN.S16043