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[Breast cancer in diabetic patients].
- Source :
-
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi [Rev Med Chir Soc Med Nat Iasi] 2009 Jan-Mar; Vol. 113 (1), pp. 140-4. - Publication Year :
- 2009
-
Abstract
- Unlabelled: Many of the risk factors for postmenopausal breast cancer are related to excess estrogen exposure. Hyperinsulinemia associated with type 2 diabetes mellitus may promote breast cancer via increased peripheral production of estrogens and direct mitogenic effect of insulin itself.<br />Material and Methods: Our retro-prospective study compares breast cancer characteristics between two study groups consisting of 53 diabetic and 391 non-diabetic patients diagnosed and treated for breast cancer.<br />Results: Almost 12% of the patients presenting breast cancer were diabetic and menopause occurred at 48.71 years for diabetic patients and at 49.87 years for the non-diabetic ones. Type 2 diabetes mellitus patients were treated by diet and oral agents, had greater body mass index (32.18 kg/m2), presented well differentiated (57% in G1) but greater (68% in T2) tumors and an increased incidence of lobular (13%) and mixed type (19%) carcinoma.<br />Conclusions: Diet and physical exercises as methods for preventing type 2 diabetes mellitus together with screening strategies among diabetic patients could contribute to decreasing the incidence of breast cancer.
- Subjects :
- Aged
Aged, 80 and over
Body Mass Index
Breast Neoplasms epidemiology
Breast Neoplasms prevention & control
Carcinoma, Ductal, Breast diagnosis
Carcinoma, Lobular epidemiology
Carcinoma, Lobular prevention & control
Case-Control Studies
Diabetes Complications epidemiology
Diabetes Complications prevention & control
Diabetes Mellitus, Type 2 diagnosis
Diabetes Mellitus, Type 2 epidemiology
Diabetes Mellitus, Type 2 prevention & control
Diet, Diabetic
Exercise
Female
Humans
Incidence
Middle Aged
Obesity complications
Postmenopause
Retrospective Studies
Risk Factors
Romania epidemiology
Breast Neoplasms diagnosis
Carcinoma, Lobular diagnosis
Diabetes Complications diagnosis
Diabetes Mellitus, Type 2 complications
Subjects
Details
- Language :
- Romanian; Moldavian; Moldovan
- ISSN :
- 0048-7848
- Volume :
- 113
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
- Publication Type :
- Academic Journal
- Accession number :
- 21495309