Back to Search
Start Over
The protective role of 5-hydroxymethyl-2-furfural (5-HMF) against acute hypobaric hypoxia.
- Source :
-
Cell stress & chaperones [Cell Stress Chaperones] 2011 Sep; Vol. 16 (5), pp. 529-37. Date of Electronic Publication: 2011 Apr 15. - Publication Year :
- 2011
-
Abstract
- Our previous study showed that pretreatment with 5-hydroxymethyl-2-furfural (5-HMF) led to protection against hypoxic injury via a p-ERK-mediated pathway in vitro. Whether the protection of 5-HMF against hypoxia is effective in vivo is unknown. The present study is aimed to verify the role of 5-HMF in acute hypobaric hypoxia using Kunming mice as an in vivo model and further investigate the underlying mechanisms. Mice pretreated with or without 5-HMF for 1 h were exposed to acute hypobaric hypoxic condition for 6 h and then the survival time, the survival rate, the permeability of blood-brain barrier (BBB), the histological analysis in hippocampus and cortex, and the phosphorylation level of mitogen-activated protein kinases (ERK, JNK, and p38) were investigated. The results showed that 5-HMF significantly increased the survival time and the survival rate of mice. Accordingly, pretreatment with 5-HMF markedly attenuated acute hypobaric hypoxia-induced permeability of BBB (P < 0.01). In addition, the cellular damage extent of the hippocampus and the cortex induced by hypoxia for 6 h was also attenuated by pretreatment with 5-HMF, especially in the hippocampus CA1 region. Furthermore, the activation of ERK rather than JNK and p38 was involved in the protection of 5-HMF against acute hypobaric hypoxia. In summary, 5-HMF enhanced the survival capability of mice and decreased acute hypoxic damage to the brain, which may be associated with the effects on BBB and p-ERK.
- Subjects :
- Altitude
Animals
Blood-Brain Barrier drug effects
Blood-Brain Barrier metabolism
Blood-Brain Barrier pathology
Cerebral Cortex drug effects
Cerebral Cortex metabolism
Cerebral Cortex pathology
Extracellular Signal-Regulated MAP Kinases metabolism
Furaldehyde pharmacology
Hippocampus drug effects
Hippocampus metabolism
Hippocampus pathology
Humans
Hypoxia metabolism
JNK Mitogen-Activated Protein Kinases metabolism
Male
Mice
Phosphorylation
Signal Transduction drug effects
Survival Rate
p38 Mitogen-Activated Protein Kinases metabolism
Atmospheric Pressure
Furaldehyde analogs & derivatives
Furaldehyde chemistry
Furaldehyde therapeutic use
Hypoxia drug therapy
Hypoxia pathology
Hypoxia prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1466-1268
- Volume :
- 16
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell stress & chaperones
- Publication Type :
- Academic Journal
- Accession number :
- 21494793
- Full Text :
- https://doi.org/10.1007/s12192-011-0264-8