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New psoriasis susceptibility genes: momentum for skin-barrier disruption.

Authors :
Coto E
Santos-Juanes J
Coto-Segura P
Alvarez V
Source :
The Journal of investigative dermatology [J Invest Dermatol] 2011 May; Vol. 131 (5), pp. 1003-5.
Publication Year :
2011

Abstract

The epidermal differentiation complex gene cluster is on chromosome region 1q21.3, where the PSORS4 locus was mapped. A common deletion of two LCE genes (LCE3C_LCE3B-del) was associated with psoriasis. Individuals homozygous for the deletion have an impaired response of the skin barrier to exogenous agents, facilitating the systemic skin inflammation characteristic of psoriasis.

Subjects

Subjects :
Chromosomes, Human, Pair 1 genetics
Cornified Envelope Proline-Rich Proteins genetics
Gene Frequency
Genetic Loci
Humans
Psoriasis epidemiology
Psoriasis immunology
Sequence Deletion
Genetic Predisposition to Disease
Psoriasis genetics

Details

Language :
English
ISSN :
1523-1747
Volume :
131
Issue :
5
Database :
MEDLINE
Journal :
The Journal of investigative dermatology
Publication Type :
Academic Journal
Accession number :
21494239
Full Text :
https://doi.org/10.1038/jid.2011.14
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