Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.

Authors :: Cornelis MC
Monda KL
Yu K
Paynter N
Azzato EM
Bennett SN
Berndt SI
Boerwinkle E
Chanock S
Chatterjee N
Couper D
Curhan G
Heiss G
Hu FB
Hunter DJ
Jacobs K
Jensen MK
Kraft P
Landi MT
Nettleton JA
Purdue MP
Rajaraman P
Rimm EB
Rose LM
Rothman N
Silverman D
Stolzenberg-Solomon R
Subar A
Yeager M
Chasman DI
van Dam RM
Caporaso NE
Source :: PLoS genetics [PLoS Genet] 2011 Apr; Vol. 7 (4), pp. e1002033. Date of Electronic Publication: 2011 Apr 07.
Publication Year :: 2011
Abstract: We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.<br />Competing Interests: The authors have declared that no competing interests exist.

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