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Menopausal status affects the susceptibility of stored RBCs to mechanical stress.
- Source :
-
Vox sanguinis [Vox Sang] 2011 May; Vol. 100 (4), pp. 418-21. Date of Electronic Publication: 2010 Nov 23. - Publication Year :
- 2011
-
Abstract
- The mechanical fragility index (MFI) is an in vitro measure of sublethal injury to RBCs. In our previous experiments, we demonstrated that an increase in sublethal injury (increasing MFI) was a component of the RBC storage lesion, and that the MFI was significantly higher amongst the RBC units from male donors compared to pre-menopausal female donors during storage. It was hypothesized that hormonal or menstrual factors contributed to this difference. In this study, we found that RBC units donated by post-menopausal women demonstrated an MFI that was significantly higher than those donated by pre-menopausal women throughout storage.<br /> (© 2010 The Author(s). Vox Sanguinis © 2010 International Society of Blood Transfusion.)
Details
- Language :
- English
- ISSN :
- 1423-0410
- Volume :
- 100
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Vox sanguinis
- Publication Type :
- Academic Journal
- Accession number :
- 21488881
- Full Text :
- https://doi.org/10.1111/j.1423-0410.2010.01439.x