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Fatty liver index and mortality: the Cremona study in the 15th year of follow-up.
- Source :
-
Hepatology (Baltimore, Md.) [Hepatology] 2011 Jul; Vol. 54 (1), pp. 145-52. - Publication Year :
- 2011
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Abstract
- Unlabelled: A fatty liver, which is a common feature in insulin-resistant states, can lead to chronic liver disease. It has been hypothesized that a fatty liver can also increase the rates of non-hepatic-related morbidity and mortality. Therefore, we wanted to determine whether the fatty liver index (FLI), a surrogate marker and a validated algorithm derived from the serum triglyceride level, body mass index, waist circumference, and γ-glutamyltransferase level, was associated with the prognosis in a population study. The 15-year all-cause, hepatic-related, cardiovascular disease (CVD), and cancer mortality rates were obtained through the Regional Health Registry in 2011 for 2074 Caucasian middle-aged individuals in the Cremona study, a population study examining the prevalence of diabetes mellitus in Italy. During the 15-year observation period, 495 deaths were registered: 34 were hepatic-related, 221 were CVD-related, 180 were cancer-related, and 60 were attributed to other causes. FLI was independently associated with the hepatic-related deaths (hazard ratio = 1.04, 95% confidence interval = 1.02-1.05, P < 0.0001). Age, sex, FLI, cigarette smoking, and diabetes were independently associated with all-cause mortality. Age, sex, FLI, systolic blood pressure, and fibrinogen were independently associated with CVD mortality; meanwhile, age, sex, FLI, and smoking were independently associated with cancer mortality. FLI correlated with the homeostasis model assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (Spearman's ρ = 0.57, P < 0.0001), and when HOMA-IR was included in the multivariate analyses, FLI retained its association with hepatic-related mortality but not with all-cause, CVD, and cancer-related mortality.<br />Conclusion: FLI is independently associated with hepatic-related mortality. It is also associated with all-cause, CVD, and cancer mortality rates, but these associations appear to be tightly interconnected with the risk conferred by the correlated insulin-resistant state.<br /> (Copyright © 2011 American Association for the Study of Liver Diseases.)
- Subjects :
- Aged
Cardiovascular Diseases mortality
Cohort Studies
Fatty Liver physiopathology
Female
Follow-Up Studies
Humans
Insulin Resistance
Italy
Liver Diseases mortality
Longitudinal Studies
Male
Middle Aged
Neoplasms mortality
Prognosis
Proportional Hazards Models
Registries
Risk Factors
Survival Rate
Algorithms
Body Mass Index
Fatty Liver diagnosis
Fatty Liver mortality
Triglycerides blood
Waist Circumference
gamma-Glutamyltransferase blood
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3350
- Volume :
- 54
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hepatology (Baltimore, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 21488080
- Full Text :
- https://doi.org/10.1002/hep.24356