Back to Search
Start Over
Cardiovascular autonomic neuropathy in chronic kidney diseases.
- Source :
-
JNMA; journal of the Nepal Medical Association [JNMA J Nepal Med Assoc] 2010 Apr-Jun; Vol. 49 (178), pp. 121-8. - Publication Year :
- 2010
-
Abstract
- Introduction: This study was conducted to explore cardiovascular autonomic neuropathy and its pattern in chronic kidney disease patients.<br />Methods: Autonomic function using five standard tests was examined in 20 diabetic patients with CKD, 20 age and sex matched diabetic patients without CKD and 20 age and sex matched controls. Analysis of difference between the autonomic function was done in the three groups using Chi-square test or Fischer's test.<br />Results: Total 20 (100%) diabetic CKD patients were found to have autonomic neuropathy. Of these, 2 (10%) patients had early parasympathetic damage, 8 (40%) patients had definite parasympathetic damage, and 10 (50%) patients had combined damage. Heart rate response to standing was statistically significant (p = 0.014) among diabetic CKD patients when compared with diabetic patients without CKD. Combined form of autonomic dysfunction was more frequent in advanced stages of diabetic CKD. Three (42.85%) patients in stage 3 CKD, 4 (66.66%) patients in stage 4 CKD and 5 (71.42%) patients in stage 5 CKD, had combined autonomic failure.<br />Conclusions: Autonomic neuropathy is common in native Nepalese diabetic CKD patients. Heart rate response to standing is significantly abnormal in diabetic CKD patients in comparison with diabetes mellitus patient without CKD. Severity of autonomic dysfunction increases with severity of CKD..
- Subjects :
- Aged
Autonomic Nervous System Diseases etiology
Autonomic Nervous System Diseases physiopathology
Blood Pressure physiology
Cardiovascular Diseases etiology
Cardiovascular Diseases physiopathology
Case-Control Studies
Diabetic Nephropathies etiology
Diabetic Nephropathies physiopathology
Diabetic Neuropathies etiology
Diabetic Neuropathies physiopathology
Female
Heart Rate physiology
Humans
Male
Middle Aged
Posture physiology
Valsalva Maneuver physiology
Autonomic Nervous System Diseases diagnosis
Cardiovascular Diseases diagnosis
Diabetic Nephropathies diagnosis
Diabetic Neuropathies diagnosis
Kidney Failure, Chronic complications
Renal Insufficiency, Chronic complications
Subjects
Details
- Language :
- English
- ISSN :
- 0028-2715
- Volume :
- 49
- Issue :
- 178
- Database :
- MEDLINE
- Journal :
- JNMA; journal of the Nepal Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 21485597