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Prostacyclin: a potent stimulator of adrenal steroidogenesis.
- Source :
-
Prostaglandins [Prostaglandins] 1978 Oct; Vol. 16 (4), pp. 483-90. - Publication Year :
- 1978
-
Abstract
- The relative potencies of various prostaglandins were investigated in trypsin-dispersed cat adrenocortical cells. Prostacyclin proved to be the most potent steroidogenic prostaglandin, being 100-1000 times more potent than PGE2. This stimulant effect of prostacyclin was only partially dependent upon the presence of extracellular calcium and was associated with increased levels of cyclic AMP. These data suggest a possible role for prostacyclin in corticosteroidogenesis.
- Subjects :
- Adrenocorticotropic Hormone pharmacology
Animals
Calcium physiology
Cats
Cells, Cultured
Cyclic AMP metabolism
Dose-Response Relationship, Drug
In Vitro Techniques
Prostaglandins E pharmacology
Time Factors
Adrenal Cortex metabolism
Adrenal Cortex Hormones biosynthesis
Epoprostenol pharmacology
Prostaglandins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0090-6980
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Prostaglandins
- Publication Type :
- Academic Journal
- Accession number :
- 214824
- Full Text :
- https://doi.org/10.1016/0090-6980(78)90178-8