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Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells.
- Source :
-
Fertility and sterility [Fertil Steril] 2011 Jun 30; Vol. 95 (8), pp. 2464-6. Date of Electronic Publication: 2011 Apr 09. - Publication Year :
- 2011
-
Abstract
- Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.<br /> (Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Analysis of Variance
Autocrine Communication
Cell Adhesion
Cell Line
Coculture Techniques
Endometriosis pathology
Endometrium pathology
Epithelial Cells pathology
Female
Humans
Macrophage Colony-Stimulating Factor genetics
Peritoneum metabolism
Peritoneum pathology
RNA Interference
Time Factors
Cell Movement
Cell Proliferation
Endometriosis metabolism
Endometrium metabolism
Epithelial Cells metabolism
Macrophage Colony-Stimulating Factor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 95
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 21481374
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2011.03.026