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Unsuspected glucose-6-phosphate dehydrogenase deficiency presenting as symptomatic methemoglobinemia with severe hemolysis after fava bean ingestion in a 6-year-old boy.
- Source :
-
International journal of hematology [Int J Hematol] 2011 May; Vol. 93 (5), pp. 664-666. Date of Electronic Publication: 2011 Apr 12. - Publication Year :
- 2011
-
Abstract
- We report the occurrence of symptomatic methemoglobinemia in a previously healthy boy, who presented with severe acute hemolysis after fava bean ingestion. The methemoglobinemia revealed a previously unrecognized glucose-6-phosphate dehydrogenase (G6PD) deficiency. We discuss the pathophysiology of severe methemoglobinemia when associated with acute hemolysis, favism, and the common African G6PD A-variant [G6PD, VAL68MET, ASN126ASP]. In conclusion, screening for G6PD deficiency must be considered in symptomatic methemoglobinemia, especially in young boys, when associated with intravascular hemolysis.
- Subjects :
- Algeria
Child
Eating
Favism complications
Favism physiopathology
Glucosephosphate Dehydrogenase genetics
Glucosephosphate Dehydrogenase Deficiency complications
Glucosephosphate Dehydrogenase Deficiency physiopathology
Hemolysis drug effects
Hemolytic Agents administration & dosage
Hemolytic Agents adverse effects
Humans
Male
Methemoglobinemia complications
Methemoglobinemia physiopathology
Mutation
Vicia faba adverse effects
Favism diagnosis
Glucosephosphate Dehydrogenase blood
Glucosephosphate Dehydrogenase Deficiency diagnosis
Methemoglobinemia diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 93
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 21479984
- Full Text :
- https://doi.org/10.1007/s12185-011-0827-6