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[Clinical experience with daptomycin use in Spain. Global findings from EU-CORE database].
- Source :
-
Medicina clinica [Med Clin (Barc)] 2010 Dec; Vol. 135 Suppl 3, pp. 23-8. - Publication Year :
- 2010
-
Abstract
- The European Cubicin(®) Outcome Registry and Experience (EU-CORE) is a retrospective, non-interventional, multicenter database of daptomycin use in several European countries. This database provides information on the routine use of this antibiotic to treat various infections caused by Gram-positive microorganisms. This article describes the demography, clinical characteristics, and outcomes of patients treated in Spanish hospitals participating in the EUCORE database, as well as the types of infection and causal pathogens involved. Overall, most indications and dosing regimens of daptomycin were within the health authorities' approved criteria, although the antibiotic was sometimes used for other clinical situations and at doses higher than those currently established. Daptomycin was mainly used as rescue therapy, and the efficacy and safety of the drug were very high. The experience gained with the EUCORE database suggests that daptomycin may be suitable for application in potentially severe infections caused by several species of Gram-positive microorganisms.<br /> (Copyright © 2010 Elsevier España S.L. All rights reserved.)
- Subjects :
- Adult
Aged
Bacteremia drug therapy
Bacteremia epidemiology
Comorbidity
Cross Infection drug therapy
Cross Infection epidemiology
Endocarditis, Bacterial drug therapy
Endocarditis, Bacterial epidemiology
Enterococcus drug effects
Female
Gram-Positive Bacterial Infections epidemiology
Humans
Male
Middle Aged
Osteoarthritis drug therapy
Osteoarthritis epidemiology
Retrospective Studies
Salvage Therapy
Soft Tissue Infections drug therapy
Soft Tissue Infections epidemiology
Spain epidemiology
Staphylococcal Infections drug therapy
Staphylococcal Infections epidemiology
Treatment Outcome
Anti-Bacterial Agents therapeutic use
Daptomycin therapeutic use
Databases, Factual statistics & numerical data
Gram-Positive Bacterial Infections drug therapy
Product Surveillance, Postmarketing
Registries statistics & numerical data
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1578-8989
- Volume :
- 135 Suppl 3
- Database :
- MEDLINE
- Journal :
- Medicina clinica
- Publication Type :
- Academic Journal
- Accession number :
- 21477701
- Full Text :
- https://doi.org/10.1016/S0025-7753(10)70037-3