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Genetic determinants of susceptibility and severity in nonalcoholic fatty liver disease.
- Source :
-
Expert review of gastroenterology & hepatology [Expert Rev Gastroenterol Hepatol] 2011 Apr; Vol. 5 (2), pp. 253-63. - Publication Year :
- 2011
-
Abstract
- Nonalcoholic fatty liver disease (NAFLD) in most patients involves only simple hepatic steatosis; however, a minority develop progressive steatohepatitis. Family studies and inter-ethnic differences in susceptibility suggest that genetic factors may be important risk determinants for progressive disease. Polymorphisms in genes affecting lipid metabolism, cytokines, fibrotic mediators and oxidative stress may be associated with steatohepatitis and/or fibrosis, but most of these findings require replication. A recent finding that a nonsynonymous polymorphism in the PNPLA3 gene predicts the extent of steatosis in NAFLD has been replicated in at least eight studies, with several studies also demonstrating an association with fibrosis. A new genome-wide association study has identified several additional novel associations with NAFLD severity. Other disease genes may be identified by similar approaches in the future.
- Subjects :
- Animals
Cytokines genetics
Disease Progression
Female
Genome-Wide Association Study
Humans
Inflammation Mediators metabolism
Lipase genetics
Lipid Metabolism genetics
Liver Cirrhosis genetics
Male
Membrane Proteins genetics
Mice
Non-alcoholic Fatty Liver Disease
Oxidative Stress genetics
Polymorphism, Genetic
Risk Factors
Severity of Illness Index
Fatty Liver genetics
Genetic Predisposition to Disease
Subjects
Details
- Language :
- English
- ISSN :
- 1747-4132
- Volume :
- 5
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Expert review of gastroenterology & hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 21476920
- Full Text :
- https://doi.org/10.1586/egh.11.18