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Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes.
- Source :
-
Science (New York, N.Y.) [Science] 2011 May 06; Vol. 332 (6030), pp. 729-32. Date of Electronic Publication: 2011 Apr 07. - Publication Year :
- 2011
-
Abstract
- The unfolded protein response (UPR), which is activated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum, has been implicated in the normal physiology of immune defense and in several human diseases, including diabetes, cancer, neurodegenerative disease, and inflammatory disease. In this study, we found that the nervous system controlled the activity of a noncanonical UPR pathway required for innate immunity in Caenorhabditis elegans. OCTR-1, a putative octopamine G protein-coupled catecholamine receptor (GPCR, G protein-coupled receptor), functioned in sensory neurons designated ASH and ASI to actively suppress innate immune responses by down-regulating the expression of noncanonical UPR genes pqn/abu in nonneuronal tissues. Our findings suggest a molecular mechanism by which the nervous system may sense inflammatory responses and respond by controlling stress-response pathways at the organismal level.
- Subjects :
- Animals
Bacterial Load
Caenorhabditis elegans microbiology
Caenorhabditis elegans Proteins genetics
Caenorhabditis elegans Proteins metabolism
Down-Regulation
Endoplasmic Reticulum metabolism
Intestinal Mucosa metabolism
Membrane Proteins genetics
Membrane Proteins metabolism
Mitogen-Activated Protein Kinases genetics
Mitogen-Activated Protein Kinases metabolism
Mutation
Pharynx metabolism
Pseudomonas aeruginosa pathogenicity
Receptors, G-Protein-Coupled genetics
Signal Transduction
Stress, Physiological
Transcription, Genetic
Up-Regulation
Caenorhabditis elegans genetics
Caenorhabditis elegans immunology
Caenorhabditis elegans Proteins physiology
Genes, Helminth
Immunity, Innate
Pseudomonas aeruginosa immunology
Receptors, G-Protein-Coupled physiology
Sensory Receptor Cells physiology
Unfolded Protein Response genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 332
- Issue :
- 6030
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 21474712
- Full Text :
- https://doi.org/10.1126/science.1203411