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Combined [18F]fluorodeoxyglucose positron emission tomography and computed tomography for detecting contralateral neck metastases in patients with head and neck squamous cell carcinoma.
- Source :
-
Oral oncology [Oral Oncol] 2011 May; Vol. 47 (5), pp. 376-80. Date of Electronic Publication: 2011 Apr 05. - Publication Year :
- 2011
-
Abstract
- We evaluated the clinical utility of combined [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT), as well as CT and magnetic resonance imaging (MRI) in identifying nodal metastases in the contralateral neck in patients with head and neck squamous cell carcinoma (HNSCC). A total of 114 patients were preoperatively evaluated with PET/CT and CT/MRI. Histopathologic analysis from bilateral neck dissection tissues was used as the gold standard in assessing these imaging techniques. Of the 114 patients, 63 (55%) had neck metastases and 26 (23%) had contralateral neck metastases. On a per-level basis, FDG PET/CT was significantly more sensitive and accurate than CT/MRI in the ipsilateral (88% vs. 70%, P<0.01 and 93% vs. 89%, P<0.01, respectively) and contralateral (52% vs. 36%, P<0.01 and 91% vs. 90%, P=0.039, respectively) neck. PET/CT and CT/MRI were less sensitive in detecting contralateral than ipsilateral neck metastases due to the lower incidence of metastases and smaller nodes on the contralateral side. Combined PET/CT is superior to CT/MRI in detecting metastatic neck nodes in HNSCC patients. However, PET/CT may not abrogate the need for contralateral neck surgery or radiotherapy in these patients.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell surgery
Female
Fluorodeoxyglucose F18
Head and Neck Neoplasms diagnosis
Head and Neck Neoplasms surgery
Humans
Lymphatic Metastasis
Male
Middle Aged
Neck Dissection methods
Neoplasm Staging
Predictive Value of Tests
Radiopharmaceuticals
Sensitivity and Specificity
Carcinoma, Squamous Cell secondary
Head and Neck Neoplasms pathology
Positron-Emission Tomography methods
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0593
- Volume :
- 47
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Oral oncology
- Publication Type :
- Academic Journal
- Accession number :
- 21470899
- Full Text :
- https://doi.org/10.1016/j.oraloncology.2011.03.018