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Identification of trans-tiliroside as active principle with anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects from Potentilla chinesis.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2011 May 17; Vol. 135 (2), pp. 515-21. Date of Electronic Publication: 2011 Apr 02. - Publication Year :
- 2011
-
Abstract
- Aim of the Study: The present study was carried out to isolate and identify trans-tiliroside as principal compound with anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects from Potentilla chinesis.<br />Materials and Methods: A bioactive compound, trans-tiliroside was isolated from the ethanol extract of Potentilla chinesis and its administration dose was optimized and patented. The normal, alloxan-induced diabetic mice and streptozotocin-induced diabetic rats were used to evaluate the anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects of trans-tiliroside from Potentilla chinesis. Biochemical parameters were assayed in blood samples of different groups of alloxan-induced diabetic mice and streptozotocin-induced diabetic rats.<br />Results: The level of fasting serum glucose levels, triglycerides (TG) and total cholesterol (TC) in alloxan-induced diabetic mice were significantly decrease after daily oral administration of trans-tiliroside in normal and diabetic mice at doses of 0.4, 0.8 and 1.6 mg/kg/day, for 15 days. Blood glucose level was significant decrease in STZ induced diabetic rats by trans-tiliroside (1.2 and 0.3mg/kg body weight for 10 weeks). The content of TC, low density lipoprotein (LDL-C) and TG levels were decreased and high density lipoprotein (HDL-C) content was increased, so lipid metabolism was improved. Moreover, trans-tiliroside revealed antioxidant activity as shown by increased activities of superoxide dismutase (SOD), decreased level of malondialdehyde (MDA) in diabetic rats. Histological morphology examination showed that the trans-tiliroside restored the damage of pancreas tissues in rats with diabetes mellitus.<br />Conclusion: Trans-tiliroside, a constituent from Potentilla chinesis, revealed significant anti-hyperglycemic, anti-hyperlipidemic and antioxidant activities.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Alloxan
Animals
Blood Glucose analysis
Diabetes Mellitus, Experimental blood
Dose-Response Relationship, Drug
Flavonoids administration & dosage
Flavonoids isolation & purification
Male
Mice
Rats
Rats, Sprague-Dawley
Streptozocin
Antioxidants pharmacology
Flavonoids pharmacology
Hypoglycemic Agents pharmacology
Hypolipidemic Agents pharmacology
Potentilla chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7573
- Volume :
- 135
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 21463674
- Full Text :
- https://doi.org/10.1016/j.jep.2011.03.062