Valproate for the treatment of medication-induced impulse-control disorders in three patients with Parkinson's disease.

Authors :: Hicks CW
Pandya MM
Itin I
Fernandez HH
Source :: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2011 Jun; Vol. 17 (5), pp. 379-81. Date of Electronic Publication: 2011 Apr 02.
Publication Year :: 2011
Abstract: Impulse-control disorders (ICDs) are becoming more commonly recognized in the Parkinson disease (PD) population. To date, there are no definitive methods of treating dopamine dysregulation syndromes in PD patients. We sought to uncover an effective treatment option for future study. We report a series of 3 PD patients with ICDs who were effectively treated with valproate. Based on these encouraging preliminary observations, future controlled clinical trials investigating the efficacy of valproate for ICDs in PD are recommended.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Subjects :: Adult
Antiparkinson Agents adverse effects
Disruptive, Impulse Control, and Conduct Disorders chemically induced
Humans
Levodopa adverse effects
Male
Middle Aged
Parkinson Disease drug therapy
Anticonvulsants therapeutic use
Disruptive, Impulse Control, and Conduct Disorders drug therapy
Valproic Acid therapeutic use

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