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Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1993; Vol. 3 (6), pp. 1137-1140. - Publication Year :
- 1993
-
Abstract
- Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pueumonia activity in a rat model of the disease.
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 3
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 21451734
- Full Text :
- https://doi.org/10.1016/S0960-894X(00)80302-9