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Azacytidine for the treatment of myelodysplastic syndromes in the elderly.
- Source :
-
Advances in therapy [Adv Ther] 2011 Mar; Vol. 28 Suppl 2, pp. 10-5. Date of Electronic Publication: 2011 Mar 09. - Publication Year :
- 2011
-
Abstract
- The management of myelodysplastic syndromes (MDS) in elderly patients is a significant clinical problem. The therapeutic options range from observation alone for patients with low-risk disease, lenalidomide for patients with 5q-syndrome, to 5-azacytidine (5-AZA) for patients with higher risk of disease. In this paper, we summarize the clinical course of three patients with high-risk MDS treated with 5-AZA as well as the management and supportive care measures for adverse events. As expected, based on available clinical trials data, the agent resulted in clinical and hematological improvement in these patients with acceptable side effects. 5-AZA is an attractive option for elderly patients with high-risk MDS.
- Subjects :
- Age Factors
Aged
Antimetabolites, Antineoplastic administration & dosage
Antimetabolites, Antineoplastic adverse effects
Blood Component Transfusion
Bone Marrow Examination
Humans
Male
Monitoring, Physiologic
Treatment Outcome
Anemia, Refractory, with Excess of Blasts etiology
Anemia, Refractory, with Excess of Blasts metabolism
Anemia, Refractory, with Excess of Blasts physiopathology
Anemia, Refractory, with Excess of Blasts therapy
Azacitidine administration & dosage
Azacitidine adverse effects
Bone Marrow pathology
Bone Marrow physiopathology
Life Expectancy
Myelodysplastic Syndromes complications
Myelodysplastic Syndromes metabolism
Myelodysplastic Syndromes pathology
Myelodysplastic Syndromes physiopathology
Myelodysplastic Syndromes therapy
Pancytopenia complications
Pancytopenia metabolism
Pancytopenia physiopathology
Pancytopenia therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1865-8652
- Volume :
- 28 Suppl 2
- Database :
- MEDLINE
- Journal :
- Advances in therapy
- Publication Type :
- Academic Journal
- Accession number :
- 21431505
- Full Text :
- https://doi.org/10.1007/s12325-010-0097-3