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Clinical significance of pretreatment C-reactive protein in patients with advanced nonsquamous, non-small cell lung cancer who received gefitinib.
- Source :
-
Oncology [Oncology] 2010; Vol. 79 (5-6), pp. 355-62. Date of Electronic Publication: 2011 Mar 24. - Publication Year :
- 2010
-
Abstract
- Purpose: We examined patients with advanced nonsquamous, non-small cell lung cancer (NSCLC) to evaluate epidermal growth factor receptor (EGFR) mutation status and serum C-reactive protein (CRP) for their associations with response to gefitinib therapy and for prognostic impacts.<br />Methods: Serum levels of CRP from 79 Japanese patients with advanced nonsquamous NSCLC were measured before the start of gefitinib. We used the peptic nucleic acid-locked nucleic acid clamp method to determine their EGFR somatic mutation status. We evaluated the relationship between each independent clinicopathological variable and the response to gefitinib therapy and the risk factors associated with prognosis.<br />Results: Having CRP-positive serum and having wild-type EGFR were both independent negative predictive factors for the response to gefitinib treatment by multivariate logistic regression model analysis. Having CRP-positive serum and having wild-type EGFR were significant independent negative prognostic factors for survival based on multivariate analysis.<br />Conclusions: Having CRP-positive serum predicted a lack of response to gefitinib therapy independent of EGFR mutational status. Both CRP-positive serum and wild-type EGFR were independent poor prognostic factors in patients with nonsquamous NSCLC who received gefitinib therapy.<br /> (Copyright © 2011 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Aged, 80 and over
C-Reactive Protein immunology
Female
Gefitinib
Humans
Japan
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Prognosis
Antineoplastic Agents therapeutic use
C-Reactive Protein analysis
Carcinoma, Non-Small-Cell Lung blood
Carcinoma, Non-Small-Cell Lung diagnosis
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Non-Small-Cell Lung genetics
ErbB Receptors genetics
Lung Neoplasms blood
Lung Neoplasms diagnosis
Lung Neoplasms drug therapy
Lung Neoplasms genetics
Quinazolines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0232
- Volume :
- 79
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 21430404
- Full Text :
- https://doi.org/10.1159/000323486