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[Subclinical carotid atherosclerosis in patients with familial combined hyperlipidemia. Two years follow-up after treatment with high doses of atorvastatin].
- Source :
-
Medicina clinica [Med Clin (Barc)] 2012 Jan 21; Vol. 138 (1), pp. 1-6. Date of Electronic Publication: 2011 Mar 22. - Publication Year :
- 2012
-
Abstract
- Background and Objective: Familial combined hyperlipidemia (FCH) is a genetic model of atherogenic dyslipidemia with insulin resistance and early coronary disease. Our objective was to evaluate the presence of carotid alterations as a marker of systemic atherosclerosis in subjects with FCH and assess the effect of 80 mg of atorvastatin per day in carotid plaque thickness after 2 years.<br />Subjects and Methods: 100 non diabetic subjects with FCH in primary prevention were consecutively included. Clinical and biochemical parameters and carotid ultrasonography were performed. Subjects with carotid plaque started treatment with 80 mg of atorvastatin per day for 2 years.<br />Results: 29% of subjects had carotid plaques. We did not find significant differences in any of the parameters between subjects with presence or absence of carotid plaques. Twenty subjects with carotid plaques accepted/agreed to participate in the interventional study. Two years follow-up showed a significant reduction in LDLc (30%) and carotid plaque thickness (10%).<br />Conclusion: Carotid ultrasonography is useful to detect subclinical atherosclerosis in high risk cardiovascular patients such as subjects with FCH. Treatment with high doses of atorvastatin induces the regression of carotid plaque thickness after 2 years follow-up. Our results suggest that intensive treatment with atorvastatin could be useful to reduce the development of cardiovascular disease in this group of patients.<br /> (Copyright © 2010 Elsevier España, S.L. All rights reserved.)
- Subjects :
- Atorvastatin
Carotid Artery Diseases diagnostic imaging
Carotid Artery Diseases etiology
Female
Humans
Hyperlipidemia, Familial Combined complications
Male
Middle Aged
Plaque, Atherosclerotic diagnostic imaging
Plaque, Atherosclerotic etiology
Statistics, Nonparametric
Ultrasonography
Anticholesteremic Agents therapeutic use
Carotid Artery Diseases drug therapy
Heptanoic Acids therapeutic use
Hyperlipidemia, Familial Combined drug therapy
Plaque, Atherosclerotic drug therapy
Pyrroles therapeutic use
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1578-8989
- Volume :
- 138
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Medicina clinica
- Publication Type :
- Academic Journal
- Accession number :
- 21429534
- Full Text :
- https://doi.org/10.1016/j.medcli.2010.12.009