Synthesis and in vitro insulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates.

Authors :: Kawarada H
Yoshikawa Y
Yasui H
Kuwahara S
Habata Y
Saito R
Source :: Metallomics : integrated biometal science [Metallomics] 2011 Jul; Vol. 3 (7), pp. 675-9. Date of Electronic Publication: 2011 Mar 18.
Publication Year :: 2011
Abstract: Several Zn(II) complexes (2a-e) of 1-arylmethyl-2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates (1a-e), known drug candidates for diabetic complications, were synthesized and proved to have in vitro insulin-mimetic activities, suggesting that these complexes are potential chemotherapeutics that are effective against both diabetes and diabetic complications.

Subjects :: Adipocytes drug effects
Adipocytes metabolism
Animals
Crystallography, X-Ray
Epinephrine pharmacology
Fatty Acids metabolism
Inhibitory Concentration 50
Molecular Conformation
Pyrroles chemistry
Rats
Zinc chemistry
Insulin analogs & derivatives
Pyrroles chemical synthesis
Pyrroles pharmacology
Zinc pharmacology

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